What is Femtech and Why You Need to Get into the Femtech Industry Now!

 

Femtech is short for female technology, and it refers to any type of technology that is designed to improve the health and wellbeing of women. This can include everything from fertility tracking apps to period tracking apps and even breast pumps.

Demand from the Femtech industry is growing globally as women are increasingly taking control of their health and wellbeing. The industry is expected to be worth $60 billion by 2027 according to a report by Emergen Research.

The femtech industry has seen a lot of growth in recent years, thanks in part to the rise of digital health and the increasing focus on women’s health. And it’s not just startups that are getting involved; big tech companies like Apple and Google are also making moves into the femtech space.

According to a report by the World Health Organization (WHO), around 830 women died every day from preventable causes related to pregnancy and childbirth in 2017. Maternal mortality is one of the key indicators of the health status of women. The high maternal mortality rate is a major concern for policy-makers and healthcare providers across the globe.

According to the Centers for Disease Control and Prevention (CDC), around 700 women in the US die from pregnancy-related complications every year. This is one of the key factors driving the growth of the femtech market in North America.

The lack of awareness about femtech products and solutions is a key challenge faced by players operating in the femtech market. The lack of awareness is especially a challenge for players operating in developing countries.

Athena Feminine Technologies, Sustain Natural, Sera Prognostics, HeraMED, iSono Health, Totohealth, Minerva, Nuvo, Elvie, and BioWink are a few of the major participants.

There are a number of factors driving the growth of the femtech industry, including:

• An increasing focus on women’s health: Women are increasingly taking control of their own health and wellbeing, and they’re demanding products and services that cater to their specific needs.

• The rise of digital health: Technology is playing an increasingly important role in healthcare, and femtech is benefiting from this trend.

• The growth of the wellness industry: Wellness is a booming industry, and femtech products are well-positioned to tap into this market.

• The increasing prevalence of chronic conditions: Conditions like endometriosis and PCOS are becoming more common, and femtech products can help women manage these conditions.

If you’re looking to enter the femtech space, there are a few things you should keep in mind.

First, it’s important to have a deep understanding of the needs of your target market. What problems are they trying to solve? What do they need help with?

Second, it’s important to have a strong understanding of the latest trends in digital health. What technologies are being used? What’s new and exciting?

And finally, it’s important to partner with the right people. Look for companies that share your vision and that have the resources to help you succeed.

The femtech industry is growing rapidly, and there’s a lot of opportunity for startups to make an impact. If you have a great idea and the right team in place, you could be well on your way to success.

Femtech Market Key Factor Driving Growth:

The increase in the number of awareness programs and initiatives by government organizations and non-profit organizations is a key factor driving the growth of this segment.

For instance, in May 2019, Merck KGaA launched an initiative named “Empowering the Future of Women’s Health” in collaboration with Nestlé Health Science and Pfizer Inc. This initiative is aimed at improving the lives of women by addressing the most pressing issues in women’s health.

The increase in the number of mergers and acquisitions is a key trend observed in the femtech market.

For instance, in October 2018, Procter & Gamble (P&G) acquired First Response, a provider of fertility and pregnancy tests. This acquisition will help P&G to expand its product portfolio in the femtech market.

The increase in venture capital funding is also a key trend observed in the femtech market.

For instance, in September 2018, Elvie raised $42 million in Series B funding led by Octopus Ventures. This funding will help the company to expand its product portfolio and business operations.

The increase in the number of partnerships and collaborations is also a key trend observed in the femtech market.

For instance, in March 2019, Ovia Health, a provider of fertility and pregnancy solutions, entered into a partnership with Cigna Corporation, a leading health insurance company. Under this partnership, Cigna’s customers will have access to Ovia Health’s products and services.

In conclusion, the femtech market is growing rapidly and presents a great opportunity for businesses to provide products and services that appeal to women. There are many different subcategories within the femtech industry, each with its own unique needs and requirements. Businesses that can identify these needs and target their products accordingly will be well-positioned to succeed in this rapidly growing market.

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Immunocytokines | Potentially Aid in Treatment of Glioblastoma

 

Immunocytokines are fusion proteins comprising a cytokine fused with a monoclonal antibody and are being viewed as a new class of biopharmaceuticals with great potential for cancer treatment. Immunocytokines aid in targeting specific tumors and generate immune responses to kill the tumor cells. Various antibody formats such as intact IgG and antibody fragments, along with tumor targets such as extracellular matrix components and cell membrane antigens, have been considered for development of immunocytokines. These pharmacologically active molecules have demonstrated lower toxicity and higher efficacy compared to several conventional cytokine-based therapies. Currently, immunocytokines are being studied for the treatment of various diseases besides cancer, such as chronic inflammatory diseases and autoimmune disorders.  

According to a study published in Science Translational Medicine in October 2020, a new immunocytokine-based therapy could potentially aid in treatment of glioblastoma, one of the most aggressive types of cancer affecting the brain or spinal cord. A group of scientists – led by Dario Neri and Patrick Roth from the Swiss Federal Institute of Technology and University Hospital Zurich, respectively – developed three L19-based immunocytokines, which first demonstrated anti-cancer activity in mouse models, and subsequently, in a human trail. Furthermore, in March 2021, Bright Peak Therapeutics Inc., a leading American biotechnology company developing next-generation cancer immunotherapies, announced its research collaboration with leading Japanese biopharmaceutical company, Ajinomoto Co., Inc. As part of the deal, Bright Peak signed an exclusive license agreement to use Ajinomoto’s proprietary bioconjugation technology, called AJICAP®, to develop Bright Peak Immunocytokines.

Revenue growth of the global immunocytokines market is majorly driven by factors such as rising prevalence of different types of cancer across the globe, growing awareness of early disease diagnosis and treatment among the population, and increasing demand for advanced diagnostics and therapeutics for treatment of cancer, autoimmune disorder, and other life-threatening diseases. According to the World Health Organization (WHO), cancer led to approximately 9.6 million deaths globally in 2018. Market revenue growth is further driven by factors such as increasing R&D activities for monoclonal antibodies, technological advancements in genetic sequencing techniques, and rising focus of various research and academic institutes on development of immunocytokines, particularly IL4, IL10, and TNF immunocytokines.

E-Skin Market Growth Driven by Rapid Advances in Material Science and Structural Designs

 

Electronic skin, or e skin, refers to a flexible, stretchable, and self-healing electronics that can efficiently mimic functionalities of human or animal skin. Electronic skin has diverse applications in robotics, artificial intelligence, health monitoring technologies, and prosthetics. Development of electronic skin has been a topic of research due to its relevant applications in robotics and in biomedical systems. E-skin basically protects the inner electronic system from damages and convey the mechanical stimulus in a way that is convenient for the sensor arrays. E-skin’s flexible and stretching characteristics facilitate miniaturized semiconductor components such as antennas, light-emitting diodes, compact power sources, and nanoscale drug delivery systems. Over the recent years, tremendous research and development activities have been carried out to develop a synthetic skin with self-healing capabilities similar to natural skin.

E-skin in healthcare sector can be used for prosthetics that can mimic the sense of touch, monitor for life signs, wound care, and in drug delivery. Rapidly aging global population and increasing prevalence of chronic diseases are expected to drive demand for e-skin. E-skin is an ultra-thin, flexible, wearable device that combines data and communication technologies with innovative materials, sensors, and microelectronics. Flexible displays are often integrated into the e-skin to reduce the discomfort associated with wearing bulky external monitoring devices. Over the recent years, many academic and research institutions have invested heavily in developing robust electronic skins. For instance, scientists and researchers at Stanford University of California have developed a very sensitive sensor that can be seamlessly integrated into an e-skin applied to a prosthetic limb. In a similar tandem, scientists from the Korea Institute of Machinery and Materials in South Korea have developed an e-skin for a prosthetic hand that can sense intensity of force, stress, or pressure to help a person recognize shape and texture of an object.

In February 2022, a breakthrough research study was published in the journal Science Robots wherein a team of researchers from Pohang University of Science & Technology (POSTECH) developed an electronic skin that can sense tactility in a way similar to humans. Researchers have developed an artificial sensory receptor that generates spike signals on its own and created an electronic skin that can send signals simultaneously to be analysed in real time. The research study was conducted with backing from Basic Research Laboratory Program and the Brain Convergence Research Program through the National Research Foundation of Korea.

In a research study published in January 2022, a team of Chinese researchers have created a flexible electronic skin that is equipped with sensors, wireless transmitters, and tiny vibrating magnets that offer haptic feedback to users. Attachment of these patches to various parts of the body such as hand, forearm, or knee can enable the system to record movements of the users and transmit them to robotic devices. The research has been published in the journal Science Advances.

Major companies in the e-skin market include Medidata Solutions, Intellisense Technology, Plastic Logic GmbH, Rotex Global, LLC, Smartlifeinc Limited, VivaLNK, Inc., Xenoma Inc., Xsensio, Chrono Therapeutics Inc., and iRhythm Technologies, Inc. In February 2022, deep tech startup, Touchlab raised £3.5 million in seed funding round. Touchlab develops tactile sensing e-skin for robots. Touchlab’s e-skin is thinner than human skin and can easily be retrofitted without reducing the robot’s or gripper’s degrees-of-freedom. Touchlab’s e-skin can withstand a high load, sense direction in 3D and can endure harsh environment such as acid, high and low temperatures, and radioactive environments conferring unique capabilities to the e-skin. 

eHealth Market Size Worth USD 314.55 Billion by 2027 | Asia Pacific region is anticipated to grow with a significant CAGR of 23.1%

 

An introduction to eHealth Market Report

The global eHealth market is forecasted to be worth USD 314.55 Billion by 2027, according to a current analysis by Emergen Research. The market is witnessing increased demand in the past years, owing to the surge in the prevalence of smartphones and the emergence of advanced technologies in the medical sector. Digital health has emerged as a triumphant venture, attracting several organizations and industries from outside the healthcare domain.

The global eHealth market report is categorized based on product type, application, end-use industry, region, and competitive backdrop. Under this section, the most fundamental segments of the eHealth market have been emphasized to help the targeted readers and the companies involved in this sector make optimal business decisions and strengthen their COVID-19 preparedness. The market’s regional outlook offers actionable insights into the contribution of various regions to the growth of the eHealth market.

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The demand-supply dynamics and pricing structures of the leading regional segments have been deeply considered to assess the current and future eHealth market valuations. Moreover, this section throws light on the key growth prospects for the eHealth market during the forecast period. Hence, toward the end of the report, the competitive landscape of the eHealth market has been emphasized. The market is highly consolidated due to the presence of a large number of companies.

Knowing the trends influencing the industry performance

Stakeholders, marketing executives and business owners planning to refer a eHealth market research report can use this study to design their offerings and understand how competitors attract their potential customers and manage their supply and distribution channels. When tracking the trends researchers have made a conscious effort to analyse and interpret the consumer behaviour. Besides, the research helps product owners to understand the changes in culture, target market as well as brands so they can draw the attention of the potential customers more effectively.

The report entails detailed information on the eHealth market players current market positions, past performances, production and consumption patterns, demand and supply graphs, sales network, distribution channels, growth opportunities, and major threats and risks associated with their development.

This report focuses on top manufacturers in global market, with production, price, revenue and market share for each manufacturer, covering

GE Healthcare, Allscripts, Cerner Corporation, Philips, IBM Corporation, Mckesson, Medtronic, Inc., Epic Systems, Cisco Systems, and Optum, among others.

For the purpose of this report, Emergen Research has segmented into the global eHealth Market on the basis of product and services, end-user, and region:

• Product and Services Outlook (Revenue, USD Billion; 2017-2027)
  • eHealth Solutions
    1. Electronic Health Records/Electronic Medical Records Solutions
    2. Picture Archiving and Communication Systems & Vendor Neutral Archive Systems (PACS & VNAS)
    3. Pharmacy Information Systems
    4. Medical Apps
    5. Laboratory Information Systems (LIS)
    6. Personal Health Record & Patient Portals
    7. Chronic Care Management Apps
    8. Clinical Decision Support Systems
    9. Telehealth Solutions
    10. Healthcare Information Exchange (HIE)
    11. Radiology Information Systems (RIS)
    12. E-Prescribing Solutions
    13. Cardiovascular Information Systems
    14. Other Specialty Information Management Systems
  • eHealth Services
    1. Remote Monitoring Services
    2. Diagnosis & Consultation Services
    3. Database Management Services
    4. Treatment Services
    5. Healthcare System Strengthening Services

• End-User Outlook (Revenue, USD Billion; 2017-2027)
  • Pharmacies
  • Healthcare Payers
  • Healthcare Consumers
  • Healthcare Providers
    1. Hospitals
    2. Home Healthcare Agencies, Nursing Homes, and Assisted Living Facilities
    3. Ambulatory Care Centers
  • Others End Users

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Geographically, this report studies the key regions, focuses on product sales, value, market share and growth opportunity in these regions, covering:

United States

Europe

China

Japan

Southeast Asia

India

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In this report, the authors have closely discerned the primary factors influencing the global eHealth market growth. The eHealth market report’s major components also include end-user landscape, solutions and services offered by the leading companies, technological innovations, critical industry-verified facts and figures, and the current as well as emerging market trends.

There are many questions the research attempts to answer:

1. Who is currently purchasing your product or service worldwide?
2. Who are your immediate competitors?
3. What will be the price of the products and services across different continents?
4. What are the trends affecting the performance of the eHealth market?
5. What features do the customers look for when they purchase eHealth?
6. What problems will vendors operating in the eHealth market encounter?
7. What needs are the prominent manufacturers trying to meet by the forecast period 2026?
8. What opportunities can prominent leaders see on the horizon?
9. How will the competitive landscape look like between the forecast period 2019 to 2026?

Why Choose Emergen Research?

1. Regional demand estimation and forecast
2. Pre-commodity pricing volatility
3. Technological updates analysis
4. Location Quotients Analysis
5. Raw Material Sourcing Strategy
6. Competitive Analysis
7. Product Mix Matrix
8. Vendor Management
9. Cost Benefit Analysis
10. Supply chain optimization analysis
11. Patent Analysis
12. Carbon Footprint Analysis
13. R & D Analysis
14. Mergers and Acquisitions

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Sensor Fusion: Combination of Multiple Sensors for Enhanced Measurement Estimations

 

Sensor Fusion, also known as multi-sensor, is the art of integrating multiple physical sensors to enhance the application and system performance. Sensors are now deployed in a broad spectrum of applications, such as smart mobile devices, automotive systems, healthcare, oil exploration, climate monitoring, and industrial controls. Sensors are used everywhere, and now the advancement in sensor technology is enabling them to mimic human beings. This is possible now because of sensor fusion technology. Sensor fusion leverages a microcontroller to combine the individual data collected from multiple sensors to get a more reliable and precise overview of the data. Sensor fusion enables context awareness, which, in turn, can extensively benefit the Internet of Things (IoT).

Sensor fusion is the ability to bring together input from multiple radars, lidars, and cameras to form a single model or a picture of the vehicle’s surrounding. The resulting model is an accurate representation as it balances the strengths of different sensors. Sensor fusion dynamically improves the lane detection performance as more sensors are used to boost the perception capability. Sensor fusion collects data from each sensor used through software algorithms to offer the most comprehensive and accurate environmental model. The escalating use of sensor fusion in consumer electronics and automotive applications is propelling the sensor fusion market’s growth. According to Emergen Research, the Global Sensor Fusion Market is forecast to attain a market valuation of USD 16.72 Billion by 2027, registering a remarkable CAGR of 19.6%.

Importance and Working of Sensor Fusion Algorithms

Sensor fusion algorithms integrate real-time sensor data that assists in reducing doubts in the object’s location and position. They combine data from several sensors to estimate the correct positions of the objects. Sensor fusions mostly rely on data from numerous same types of sensors, also known as “competitive configuration”. However, when merging data from different types of sensors, such as amalgamation of object proximity data and speedometer data, more often results in an in-depth interpretation of the object examined.

For instance, during a foggy climate, a radar sensor offers more precise data than a LiDAR sensor would. Whereas, in clear weather, LiDAR sensors’ spatial resolution is much more reliable than radar sensor. Every sensor has its own pros and cons, which is why sensor fusion algorithms take into consideration multiple types of sensors. The data from these various sensors are complementary, and the setup is typically called a complementary configuration.

Due to each sensor’s strengths and weaknesses, a robust algorithm gives preference to some critical data points over others. For instance, speed sensors are more precise than parking sensors, so those sensors are mostly preferred. The importance varies, and they generally depend on the specific use. 

Sensor fusion algorithms examine all the input data and generate output with enhanced accuracy and reliability. To measure the kinematic state of a vehicle, two equations and models are applied ‒ namely predict equation that used motion model and update equation that uses the measurement model. The motion model gives data about an object in periodic intervals, and the measurement type is more involved with the vehicle sensors’ dynamics. One of the essential foundations of these algorithms is the Kalman filter.

·       Overview of Kalman Filter

A Kalman filter refers to an equation that obtains data inputs from numerous sources and predicts unknown values, even in the case of augmented signal noise. Majorly applicable in control and navigation tech, Kalman filters confer the prediction of uncertain values more precisely than specific predictions by single measurement method.

As these algorithms are the most commonly used sensor fusion application and provide a resilient foundation for the concept, sensor fusion and Kalman filters are generally considered synonymous. Kalman filters are one of the most popular algorithms in sensor fusion and were invented by Rudolph Kalman in 1960. Now the algorithm is widely deployed in smartphones and satellites from navigation and tracking.

Factors Influencing the Growth of Sensor Fusion Market

The escalating trend of autonomous vehicle and advanced driver assistance systems (ADAS) are further augmenting the need for new radar, GNSS, lidar, and camera sensors in the vehicles. The increasing penetration of smartphones globally and the augmenting trend of micro-sized electronics are anticipated to add to traction to the market’s growth. Moreover, the growing application of fusion technologies to survey and predict environmental conditions, such as temperature, pressure, and humidity, have created an added demand for sensor fusion technologies.

The augmenting need for application-based location detection is attracting consumers and investors to invest in the technology and deploy them across the globe, thereby contributing to the market growth. The increasing advancement in ADAS and the surging use of the GPS-Inertial Measurement Unit fusion is highly beneficial for solving mounting errors. For instance, Tesla’s Autopilot automated driving feature, which is an example of ADAS, has the ability to carry out operations like maintaining the lane of the vehicle on a highway by predicting the accurate location of the vehicle from the data obtained from a forward-facing camera and steering control.

Collaborations and agreements are a common occurrence in the market and are primarily contributing to the market’s expansion. For instance, in April 2020, Foresight Autonomous Holdings Ltd., an Israel-based leader in automotive vision systems, joined forces with FLIR Systems Inc., to develop and commercialize the former’s QuadSight Vision System, which is based on sensor fusion, combined with infrared cameras of FLIR Systems to a broad spectrum of customers. In 2019, Ceva Inc. gained a controlling stake in the smart sensor technology business of Hillcrest Lab. Under the acquisition, CEVA’s intelligent sensing technology’s portfolio has the chance to expand to include CPU vision and AI processing for cameras and sound processing for microphones.

In December 2020, Himax Technologies Inc., joined forces with Edge Impulse to enable the accelerated development and deployment of the machine learning model. The AI vision and sensor fusion solution are designed for predictive maintenance, asset tracking, occupancy detection, and condition monitoring.

STMicroelectronics and Mobileye have formulated a strategy to develop EyeQ 5 system on chip in association with each other, to be deployed in 2020, to perform the function of central computer control and sensor fusion in the fully autonomous driving vehicles. Companies actively focused on developing technologies linked with IoT and smart driving are anticipated to create lucrative future opportunities. The increasing demand for monitoring and controlling utilities in home automation and the escalating development in robotics is forecast to influence the market growth due to sensor fusion technology’s wide application in mobile robot navigation.

Drivers of the Trans-Catheter Mitral Valve Implantation Market include Advancements in Techniques of Trans-Catheter Mitral Valve Implantation, Substantial Prevalence of Mitral Regurgitation, and Favorable Reimbursement Scenarios

Market Insights:

Mitral regurgitation (MR) is the most common heart valve disease, affecting around four million people in the U.S. Typically, open-heart surgeries are a standard mode of treatment for MR, although in certain cases, there are grave risks associated with the surgery.  Till now, patients have had to resort to medical treatment to deal with MR, but for patients with specific types of mitral valve dysfunction that leads to MR, clipping the mitral valve will be a good option, especially when the risks of undergoing surgery are dire. Transcatheter mitral valve implantation can help lower the incidences of heart failure and the resulting hospitalizations. It is a less invasive option for patients for whom open-heart surgery is not an option.

Untreated, MR can ultimately result in chronic heart failure, which is the leading reason for hospitalization in Europe and the U.S. It occurs when the mitral valve between two chambers of the heart cannot close completely, and the blood flow leaks backward. It involves symptoms like fatigue, shortness of breath, swollen feet, and inability to exercise or perform daily activities. This leads to increased stress on the heart, enlargement of the heart, heart dysfunction, and even heart failure. The demand for a treatment method is significantly high, which has urged companies and academia to explore the effectiveness of transcatheter mitral valve implantation and is also a major driver for the growth of the market.

The leading companies in the industry include Abbott Laboratories, Medtronic, LivaNova, Edward Lifesciences, MValve Technologies, HLT Medical, Colibri Heart Valve, Neovasc, NeoChord, Biotronik Private Limited, Transcatheter Technologies GmbH and Venus Medtech. The competitive landscape has witnessed numerous deals and developments recently.

Medtronic has partnered with the medical device company incubator, The Foundry, to build and invest in a company dedicated to working on an innovative transcatheter mitral repair (TMVr) technology. The partnership brings together The Foundry’s work in the transcatheter mitral valve repair and replacement field and Medtronic’s position in intellectual property and Structural Heart. The deal creates structured financial tranches from both the companies and gives Medtronic exclusive rights to the resulting corporation dubbed Half Moon Medical, subject to achieving some clinical and technical milestones. Half Moon was also awarded U.S. FDA approval for an early feasibility study in patients having severe and symptomatic MR.

While Half Moon awaits its first implants, another company, TidalHealth,  has achieved a medical milestone after successfully implanting MitraClip for treating MR in the heart. Delmarva’s first two implantations of MitraClip were conducted at TidalHealth Peninsula Regional in late September. The number of patients it can benefit will be a primary driver for the growth of the transcatheter mitral valve implantation market in the coming years, especially in regions like Europe and North America that have a high active patient count.

Teleradiology Services and AI-Based Solutions are Projected to Profit from Fresh Capital Investments

 Market Insights:

Healthcare became the only priority across the world after the onset of the COVID-19 pandemic, and while some issues came to the top of that list, the rest were put on the back burner to reduce the risk of patients getting infected. Since healthcare settings, such as hospitals and diagnostic centers, were a hotspot for the virus, it seemed unsafe for people to visit them. However, advancements in technology provided some medical professionals the opportunity to work remotely. Teleradiology is when a radiologist interprets medical images without being at the location where the images are generated. Teleradiology services are now being offered by mobile imaging companies, hospitals, urgent care facilities, and private practices. 

Teleradiology has been prevalent across the modern radiology practice and has aided practices in getting multispecialty, after-hours, and geographic coverage. It reduces turnaround time and increases underserved access. However, the quality assurance involved in offsite interpretation is crucial, and IT integration solutions might be the solution smaller practices need to successfully adopt teleradiology. After the imaging for elective procedures’ backlog was given the green light in the third quarter and teleradiology services and AI-based solutions are projected to profit from fresh capital investments. Flexible payment options, scale-up in capacity, redistribution of workload, and reduced human contact, will help the growth of the teleradiology services market. Dental teleradiology is also a growing sector in the teleradiology services market.

A recent survey conducted by American College of Radiology found that 45% of radiologists who were not connected to a teleradiology company resorted to teleradiology. Radiology practices can opt for coverage of a fixed portion of their projected volume internally and depend on teleradiology firms or business-to-business and spot-market radiologist hires to take the additional cases, thereby lowering the fixed labor costs. In the pre-COVID-19 phase, numerous radiologists were already using home PACS workstations. Another survey published in the Journal of American College of Radiology indicated that before the COVID-19 outbreak, teleradiology had only been utilized for call as well as overnight shifts. After the pandemic outbreak, more and more practices have been installing home workstations and switching daytime shifts to their internal teleradiology. 

The leading companies in the sector include viz., Teleradiology Solutions, Philips Healthcare, USRAD Holdings, Inc., MEDNAX, Everlight Radiology, ONRAD, Inc., AGFA Healthcare, RAMSOFT, Inc., Telediagnostic Solutions PVT. LTD., and CARESTREAM HEALTH, Inc. Recently, in June, MEDNAX, the Floride-based company, announced that it was selling its Radiology Solutions business line and change its name to the previous ‘Pediatrix Medical Group.’ 

Research Fundings from Governments Worldwide Have Played an Instrumental Role In Driving The Growth Of The Single Cell Sequencing Market

Market Insights:

Single CellSequencing is a next-generation sequencing (NGS) technique primarily used to analyze the variations in protein and genetic information between cells to extract genetic data on microorganisms, which are otherwise challenging to cultivate at the individual cell level and to comprehend their particular roles in the micro-environment better. Research studies in the field of single cell sequencing focus on a wide array of applications right from immunotherapy, neurobiology, and cancer treatment to, in the latest feat, COVID-19.

A group of MIT researchers recently found a way to recover information through single cell sequencing. The team used a modified version of the Seq-Well technique, which gave them the capacity to extract ten times more information from each cell in a given sample. The increased information extraction resulting from the novel approach would help researchers gain more knowledge about the gene expression in each cell and help them find subtle yet critical variations between healthy cells and dysfunctional cells.

The leading companies in the industry include Thermo Fisher Scientific Inc., 10x Genomics Inc., Becton, Dickinson & Company, Illumina, Bio-Rad, Fludigim, BGI, F Hoffman-La Roche Ltd., Qiagen, and Oxford Nanopore Technologies. 10x Genomics recently announced the acquisition of the Boston-based ReadCoor, Inc.. The company’s second in situ sequencing takeover was valued at USD 350 million in cash and stock consideration. It had previously announced the acquisition of Cartana, the  Stockholm-based developer of in situ RNA analysis technology, in August. 

In situ methods allow researchers to measure a colossal number of molecules directly through the precise location of the molecule at sub-cellular resolution. The newly-acquired capabilities might complement 10x Genomics Chromium Single Cell and Visium Spatial platforms and help the company establish the foundation for its third tech platform, widening its consumer base and facilitating the new translational as well as clinical applications.

The most relevant development recently pertains to the ongoing COVID-19 pandemic. The changes in the SARS-CoV-2 virus genome in the transmission of the infection have remained unclear. A team of University of Chicago researchers has used a new approach, a technique named FD-seq, which is a high-throughput single cellsequencing approach to sequence single cells applicable for paraformaldehyde (PFA) treatment. 

The team examined the immune response of human lung cells infected by coronavirus OC43, a virus belonging to the same family as SARS-CoV-2, which causes the common cold, which has been used successfully in drug discovery to prevent the replication of SARS-CoV-2 in vitro. Mining this ‘biological bitcoin’ could have inestimable benefits, and the worth of genetic information will continue to be a major driver for the growth of the single cell sequencing market.  However, the costs of it might also be similarly prohibitive for most consumers, impeding its accessibility and, subsequently, its growth.

Increasing Interest in Pharmaceutical Applications of Gene Editing is Boosting the Growth of the Gene Editing Market

Market Insights:

The emergence of versatile gene editing technologies in recent years has enabled researchers to economically and seamlessly introduce sequence-specific modifications into genomes of a wide range of organisms and cell types. Some of the prevalent core technologies in the field are transcription activator-like effector nucleases (TALENs), homing endonucleases or meganucleases, clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), and zinc-finger nucleases (ZFNs).

In the past few years, CRISPR-Cas9 gene editing has been in focus for the precision of the gene edits carried out in the procedure and some extremely charged patent disputes. The field is now progressing swiftly, with several start-ups aiming to leverage the CRISPR ‘molecular scissors’ commercially. Even though CRISPR’s application scope is fairly extensive, it is not surprising that most companies are exploring its pharmaceutical applications, particularly pertaining to immunology, cancer, and rare diseases. The technology promises cures, either by editing cells in the body or by engineering cells isolated from the body before restoring them. Earlier this year, Crispr Therapeutics and Vertex announced a joint effort to work on CTX001, an investigational ex vivo CRISPR/Cas9 gene editing procedure for patients with Sickle Cell Disease (SCD) and Transfusion-Dependent Beta-Thalassemia (TDT). The two organizations recently announced that the gene-edited therapy was granted the Priority Medicines (PRIME) designation by the European Medicines Agency (EMA).

This increasing interest in pharmaceutical applications of gene editing is boosting the growth of the market; however, recent developments in the sector have also raised some concerns. Back in 2015, researchers conducted the first experiment to modify human embryos, which kickstarted further investigation into human genome editing. A recent series of experiments published on bioRxiv has raised some safety concerns about DNA changes and on-target complexities following CRISPR-Cas9 genome editing. The field demands much more investigation before it can be scaled. Since CRISPR is a prominent contributor to the overall revenue of the gene editing industry, unfavorable research findings might hinder the growth of the gene editing market for a few years. 

Other leading companies operating in the market include Thermo Fisher Scientific, Lonza, GenScript, Vigene Biosciences, Transposagen Biopharmaceuticals, Genecopoeia, Calyxt, Editas Medicine, EpiGenie, and Editas Medicine. Intellia Therapeutics is also a company working on CRISPR-Cas9 gene editing to develop genome editing treatments to cure genetic diseases. U.K.’s Medicines and Healthcare products Regulatory Agency (MHRA) has just given the green light to a Phase 1 clinical trial for Intellia’s NTLA-2001 gene therapy for hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN). With companies investing and exploring further into the applications of gene editing, the market is expected to exhibit significant research-backed growth in the coming years.